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Lablab purpureus subsp. purpureus (L.) Sweet

Summary
It is commonly known as Sem. It belongs to the family Fabaceae and is a good source of protein. It is consumed in the form of unripe pods, green mature and dry seed. Sem has anti-inflammatory and antioxidant properties that help to counteract oxidative stress. Genistein, Santene, Dolichin are some of its bioactive compounds. Genistein is associated with strong anti-inflammatory activity through inhibition of various signaling pathways such as nuclear factor kappa-B (NF-κB), prostaglandins (PGs), inducible nitric oxide synthase (iNOS), proinflammatory cytokines and reactive oxygen species (ROS).

Mode of Consumption : Fried, boiled, seeds cooked fresh and dried
Plant Details Agro-climatic Zone Vernacular Names Pictures
Scientific Name: Lablab purpureus subsp. purpureus (L.) Sweet
Family: Fabaceae Lindl.
Class: Magnoliopsida
Order: Fabales
Genus: Lablab Adans.
Fruiting Season: January to March
Parts: Pods
  • The North-Eastern Hill Region
  • The Maharashtra Plateau Region & The Western Coastal Region
  • The Upper Ganga Plain Region & The Middle Ganga Plain Region
  • The Lower Ganga Plain Region
 Assam : Sem
Maharashtra : Pavate
Manipur : Hawi uri
Mizoram : Be-pui
Nagaland : Kecu
Uttar Pradesh : Bhatvas, Shimi, Sem
West Bengal : Avare

Pods
Compound/Extract Activity Mode of Action Marker/References
Seed flourAnti-inflammatoryIn vitro analysis revealed that Lipid peroxide and TNF-α levels were significantly reduced in malnourished + Lablab seed flour fed rats.TNF-α[1]
ExtractAnti-obesityExtract enhanced phosphorylation of AMPK, indicating that AMPK was a critical regulator of DLL-Ex-mediated inhibition of hepatic lipid accumulation, possibly through its antioxidative effect.AMPK[3]
LectinImmunomodulatoryLectin treated mice showed an up-regulated immunoregulatory cytokine IL-2 in contrast to severely declined levels in control mice. Lectin down-regulated various pro-angiogenic gene expressions, such as HIF-1α, VEGF-α, NF-κB, I-κB, MMP-2 and MMP-9 in both in-vivo ascitic and solid tumours.IL-2, HIF-1α, VEGF-α, NF-κB, I-κB, MMP-2, and MMP-9 [4]
GenisteinAntioxidantGenistein significantly inhibited the translocation of p65 subunit, action of NF-κB, the concentration of PGE-2, IL-6, TNF-α. It also decreased the COX-2, nitrite productions, decreased the mRNA expression of COX-2 and iNOS in LPS induced hPBMCs cells.p65 subunit, NF-κB, PGE-2, IL-6, TNF-α, COX-2, COX-2, and iNOS[5]
GenisteinAnti-inflammatoryGenistein inhibits the signal transduction pathway relating to Toll-like receptor stimulation and NF-κB activation in hPBMCs cells.NF-κB[6]
Polyphenolic fractionAnti-inflammatoryThe up-regulated expression of IL-6, TNF- α, COX-2 and PGE2 gene expression during arthritic induction was significantly suppressed by administration of polyphenolic fraction.IL-6, TNF- α, COX-2 and PGE2[6]
Major Class Metabolites (Content of bioactives: mg/100g Fresh Weight)
AlcoholPentanol: [7]
AmylalkoholIsopentyl alcohol: [7]
Cyclic hydrocarbonNorbornene: [7]
EsterIsopentyl formate: , Methyl Butyrate: [7]
Heterocyclic CompoundGenistein: [5]
HydrocarbonSantene: [7]
PterocarpanDolichin: [7]
Thiazole4-Methyl thiazole: [7]
Triterpene3-0 (alpha - L. rhamnopyranosyl (1→2) (1→2)- beta -D-glucopyranosiduromic acid)-28-0- (beta-D-glucopyranosyl) 24-epi-hederagenin: , 3-0-(alpha-L-rhamnopyranosyl (1→2)-beta D-galactopyranosyl (1→2)-beta-D-glucopyranosiduronic acid)-28-0- (beta D-glucopyranasyl oleonic acid: , 3-0-(alpha-L-rhamnopyranosyl (1→2)-beta-D- gala etopyranosyl (1→2) beta -glucopyranosiduronic acid) - D- 28-0-(alpha-L-rhamnopyranosyl (1→2)-beta-D-glucopyranosyl) 24-epi- hederagenin: [7]
Effect Observation DOI
Disease Formulation Reference Author TKDL
Acute diarrhoeaAtisareapathyamBhaishajya RatnavaliEdited by Rajeshvaradutta Shastri, Translated by AmbikaduttashastriAyurveda
Piles, Ano rectal mass, Haemorrhoids, RicketsVelvanga ParpamAgathiyar paripooranam 400AgasthiyarSiddha
Arthritis, Swelling of Viscera Melanic fever Cough / Bronchitis ColicLablaabAl-Jaame'-li-Mufradaat-al-Advia-wal-Aghzia,Vol. IVZiya Al- Din Abdullah Ibn Al- BaitarUnani
Information from Wealth of India Reference
  • Seeds are known as febrifuge, stomachic, anti- spasmodic and with aphrodisiac properties.
 CSIR(1952).The Wealth of India, Raw materials,Vol.-III ,P.104-106, New Delhi, India
4.2, 04.2.1, 04.2.1.1, 04.2.1.3, 04.2.2.3, 04.2.2.5, 04.2.2.8
  • Beans with eggs, milk, fish, fruits, yogurt, and meat should be avoided.
CSIR-North East Institute of Science and Technology, Jorhat-6, Assam, India
CSIR-Institute of Himalayan Bioresource Technology, Palampur-61,Himachal Pradesh, India