Ziziphus jujuba
Jujube fruit is also known as the red or Chinese date, native to Southern Asia and found in almost all the regions of India. It is a small round shaped fruit with a seed in the centre, green in colour and tends to turn yellow to orange when ripe, tastes sweet and sour depending upon the varieties and region. The fruit is low in calories and rich in fibre, vitamins and other bioactive chemicals. According to reports the fruits were used as traditional Chinese medicine for two thousand years. The fruit is eaten raw when ripe, dried, made pickles and so on. According to various reports, bioactive compounds like, Alkaloids, saponins, Flavonoids, Terpenoids and Phenolic compounds are found to be present in the fruit. And due to the activities of these compounds, consumption of the fruit in a dose dependent manner may be beneficial to our health. |
Plant Details | Agro-climatic Zone | Vernacular Names | Pictures |
Scientific Name: Ziziphus jujuba Mill. Family: Rhamnaceae Juss. Class: Magnoliopsida Order: Rosales Genus: Ziziphus Mill. Fruiting Season: October to December Fruting Condition: Ripe |
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Andhra Pradesh : Badari, Ganga regi Gujarat : Baher, Ber Jammu and Kashmir : Baryan, Singli, Unnab Kerala : Badaram Tamil Nadu : Arulatotikacceti, Arulatotiyam |
Compound/Chemical | Immunomodulatory Activity | Pathway | Immunomodulatory Marker |
Fruit extracts | Antioxidant activity | Jujube extracts at various concentrations (0.25-1.0 mg/ml) inhibited DPPH radical, and its DPPH radical scavenging effect was in a dose dependent manner. | [6] |
Fruit extracts | Antioxidant activity | Jujuba extracts (0-3.0 mg/ml) protected tBHP-induced oxidation insult on PC12 cells via activation of ARE-mediated transcriptional activity. | Protection of tBHP[6] |
Fruit extracts | Antioxidant activity | Jujuba polysaccharides (0-3.0 mg/ml) possessed the potential effect to scavenge hydroxyl radicals, and the scavenging rates increased dose-dependently. | NO[6] |
Fruit seed extracts, jujuboside B | Cardiovascular activity | The fruits seeds of Z. jujuba (30, 100, or 300 mg/kg) and its active component jujuboside B (10, 30, or 100 mg/kg) were reported to exhibit anti-platelet aggregation activity. | Inhibition of anti-platelet aggregation[4] |
Fruit extracts | Cardiovascular activity | Jujuba extracts at 25 and 50 μg/ml suppressed lipid accumulation and GPDH activity in 3T3-L1 preadipocytes. | GPDH, PPAR gama, CCAAT, C/EBP alpha and beta[4] |
Fruit extracts | Anti-inflammatory activity | Jujuba extract showed anti-inflammatory effect via inhibition of nitric oxide expression. | Inhibition of NO[7] |
Fruit extracts | Anti-inflammatory activity | Jujuba extract regulated pro-inflammatory cytokine expressions under different conditions via NF-kB signaling. | NF-kB, COX-2, PGs, Inos[7][8][9] |
Fruit extracts | Immunomodulatory activity | Jujuba extract regulated pro-inflammatory cytokine expressions under different conditions via NF-kB signaling. | TNF-alpha, IL-1beta, IL-6, LPS[7][8][9] |
Major Class | Metabolites |
Acyloins | Acetoin(Whole fruit) |
Aldehyde derivatives | 2-Nonenal(Whole fruit), 2-Octenal(Whole fruit), 2-Methylbutyraldehyde(Whole fruit), Hexanal(Whole fruit), Isobutyraldehyde(Whole fruit), Furfuryl alcohol(Whole fruit), Furfural(Whole fruit), Heptanal(Whole fruit), Phenylacetaldehyde(Whole fruit), Butyraldehyde(Whole fruit), 2-Hexenal(Whole fruit) |
Alkaloid | Protopine(Whole fruit), Asimilobine(Whole fruit), Jubanine B(Whole fruit), N-Nornuciferine(Whole fruit), Zizyphine A(Whole fruit) |
Alpha camphorene | Ceanothic acid(Whole fruit) |
Alpha diketones | 2,3-Butanedione(Whole fruit), 2,3-Pentanedione(Whole fruit) |
Alpha hydroxy ketones | 1-Hydroxybutan-2-one(Whole fruit) |
Alpha-hydro gen aldehydes | Pentanal(Whole fruit) |
Amino acid | Jujubogenin(Whole fruit) |
Anthocyaninss | Flavylium(Whole fruit), Myricetin 3-O-glucoside(Whole fruit) |
Aporphines | Isoboldine(Whole fruit) |
Aryl alkyl ketones | 2-acetylfuran(Whole fruit) |
Benzoyl derivatives | Benzaldehyde(Whole fruit) |
Bisphosphonate derivatives | Colubrinic acid(Whole fruit) |
Carboxylic acid derivatives | Benzoic acid(Whole fruit), Citric acid(Whole fruit), Isobutyric acid(Whole fruit), 3-Phenylpropionic acid(Whole fruit), Propionic acid(Whole fruit), Citric acid(Whole fruit) |
Cayanidine derivatives | Leucocianidol(Whole fruit) |
Cyclopeptide alkaloid | Frangufoline(Whole fruit) |
Cytokinins | Kinetin(Whole fruit), Trans-zeatin(Whole fruit) |
Enals derivatives | Methacrolein(Whole fruit) |
Enones | Ethyl vinyl ketone(Whole fruit), Methyl vinyl ketone(Whole fruit) |
Fatty Acids derivatives | Isovaleric acid(Whole fruit), Lauric acid(Whole fruit), Decanoic acid(Whole fruit), Octanoic acid(Whole fruit), Stearic acid(Whole fruit), 2-Dodecenoic acid(Whole fruit), Undecanoic acid(Whole fruit), Heptanoic acid(Whole fruit), Docosanoic acid(Whole fruit), Palmitic acid(Whole fruit), Hexanoic acid(Whole fruit), Butyric acid(Whole fruit), Arachidic acid(Whole fruit), Palmitoleic acid(Whole fruit), Oleic acid(Whole fruit), Oleanolic acid(Whole fruit), Valeric acid(Whole fruit), Nonanoic acid(Whole fruit), Linoleic acid(Whole fruit), 2,3-Dimethylmaleic anhydride(Whole fruit), 7-Octenoic acid(Whole fruit) |
Fatty alcohol derivatives | 1-Octen-3-ol(Whole fruit), 1-Hexanol(Whole fruit), Nonan-1-ol(Whole fruit), 1-Octanol(Whole fruit) |
Fatty aldehyde derivatives | 2-Heptenal(Whole fruit), 2,4-Hexadienal(Whole fruit) |
Flavanones | Eriodictyol(Whole fruit) |
Flavone | Swertisin(Whole fruit) |
Flavonoid | Zizyberenalic acid(Whole fruit), Quercetin(Whole fruit), Myricetin 3-rutinoside(Whole fruit), Rhamnetin(Whole fruit) |
Furan derivatives | 5-Methylfurfural(Whole fruit) |
Glucosides | Roseoside(Whole fruit) |
Glycosides derivatives | 3-beta-O-(trans-p-Coumaroyl)maslinic acid(Whole fruit) |
Isoquinoline Alkaloid | Norisoboldine(Whole fruit), Berberine(Whole fruit) |
Isovaleraldehyde | 3-Methylbutanal(Whole fruit) |
Ketone derivatives | 2-Hexanone(Whole fruit), 2-Pentanone(Whole fruit), 2-Octanone(Whole fruit), Methyl isobutyl ketone(Whole fruit), 2-Nonanone(Whole fruit) |
Lactone derivatives | Gamma-octalactone(Whole fruit), Gamma-butyrolactone(Whole fruit), Gamma-nonalactone(Whole fruit) |
Oleamide | Fatty amide derivatives(Whole fruit) |
Oligopeptides | Jubanine C(Whole fruit), Amphibine H(Whole fruit), Mucronine A(Whole fruit), Mucronine D(Whole fruit) |
Pentacyclic triterpenoids | Oleanonic acid(Whole fruit), Ursolic acid(Whole fruit), Betulinic acid(Whole fruit) |
Phenolic acid | Ascorbic acid(Whole fruit) |
Phenyl methanol derivatives | Benzyl Alcohol(Whole fruit) |
Phenylalanine | Chlorogenic acid(Whole fruit) |
Phytosterols | Beta-sitosterol(Whole fruit), Stigmasterol(Whole fruit) |
Polyketides | Spinosin(Whole fruit) |
Primery alcohols derivatives | 1-Butanol(Whole fruit), Isoamyl alcohol(Whole fruit) |
Purine nucleosides | Inosine(Whole fruit) |
Pyrazines | 2,6-Dimethylpyrazine(Whole fruit), 2-Methylpyrazine(Whole fruit) |
Pyridin Alkaloid | Nicotinamide(Whole fruit) |
Pyridine carboxylic acids | 3-Pyridinecarboxaldehyde(Whole fruit) |
Pyridinecarboxylic acids | Nicotinic acid(Whole fruit) |
Rutinoside | Rutin(Whole fruit) |
Saponin | Protojujuboside A(Whole fruit) |
Sugar derivatives | 6-Deoxy-L-talose(Whole fruit) |
Tetrahydrofurans | Trans-linalool oxide(Whole fruit) |
Triterpenoids | Mauritine B(Whole fruit), Alphitolic acid(Whole fruit), Zizogenin(Whole fruit), Jujuboside E(Whole fruit), 3-cis-coumaroylmaslinic acid(Whole fruit), Betulonic acid(Whole fruit), Corosolic acid(Whole fruit), Jujuboside C(Whole fruit), Maslinic acid methyl ester(Whole fruit), Protojujuboside B1(Whole fruit), Protojujuboside B(Whole fruit), Jujuboside B(Whole fruit), Maslinic acid(Whole fruit), JujubosideA(Whole fruit) |
Vitamins | Riboflavin(Whole fruit), Folic(Whole fruit) |
Traditional Practice | Diseases | Plant Part | Additional Knowledge |
Ayurveda | Fever and rheuamntism | Fruit | Cardiometabolic factors and systemic inflammation in type 2 diabetic patients[11] |
Ayurveda | Fever and rheuamntism | Fruit | effect of Ziziphus jujube Fruit Infusion on Lipid Profiles, Glycaemic Index and Antioxidant Status in Type 2 Diabetic Patients[12] |
04.1.1, 04.1.1 |
Incompatible with milk and other dairy products. |
CSIR-North East Institute of Science and Technology, Jorhat-6, Assam, India
CSIR-Institute of Himalayan Bioresource Technology, Palampur-61,Himachal Pradesh, India |