Vitis vinifera
India is the 7th largest producer of grapes in the world with 3,125,000 tonnes in 2020. Maharashtra, Karnataka and Tamil Nadu are largest grapes producing state in the country. Grapes belonging to Vitaceae family is generally harvested from May to July. Phenolics, flavonoids and stilbenes are major secondary metabolites present in grapes and resveratrol, rutin and Coumaric acid are the major bioactive compounds. Resveratrol has been reported to show antiproliferative activity. It inhibits the tumor growth, decreasing cell proliferation and expression of p-STAT3 in tumor tissues. Rutin a flavonoid had been reported to exhibit antiproliferative activity by decreasing Bcl-2, VEGF and increases the production of p53 and Coumaric acid has antioxidant property. |
Plant Details | Agro-climatic Zone | Vernacular Names | Pictures |
Scientific Name: Vitis vinifera L. Family: Vitaceae Juss. Juss. Class: Magnoliopsida Order: Vitales Genus: Vitis L. Fruiting Season: February-March; November-January Fruting Condition: Ripe |
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Assam : Angur, Angur Karnataka : Drakshi, Drakshi Maharashtra : Angoor, Angoor Uttar Pradesh : Angoor, Angoor |
Ripe grapes. Ripe fruit with plant. |
Compound/Chemical | Immunomodulatory Activity | Pathway | Immunomodulatory Marker |
Reservatrol | Reservatrol present in grape extract inhibits Amyloid beta(1-42) fibril formation. | [2] | |
Proanthocyanidin | Anti-inflammatory activity | It helps to increase the levels of IFN gamma and IL-12 in CD11c+ dendritic cells obtained from UVB-exposed wild-type mice but not dendritic cells from UVB-exposed XPA-deficient mice. | IFN-gamma, IL-12[10 |
Proanthocyanidin | It helps to enhance in the repairing of UVB-induced DNA damage in epidermal dendritic cells. | [7] | |
Proanthocyanidin | Anti-inflammatory activity | I helps to reduce the levels of IL-10 in dendritic cells. | IL-10[7] |
Resveratrol | Anti-inflammatory activity | Inhibit the production of inflammatory factors through the activation of Sirt1. | [2] |
Resveratrol | Antiproliferative activity | Inhibits the tumor growth, decreasing cell proliferation and expression of p-STAT3 in tumor tissues | [2] |
Rutin | Antiproliferative activity | Decreses Bcl-2 , VEGF and increses the production of p53 | P53[3] |
Major Class | Metabolites |
Flavonoid | Catechins (flavan-3-ol)(Seed), Epicatechins(Seed), Epicatechin-3-O-gallate(Seed), Quercetin(Pulp), Quercetin(Skin), Kaempferol(Pulp), Kaempferol(Skin), Kaempferol(Seed), Hydroxybenzoic acid(-) |
Phenolic Acid | Gallic acid(Pulp), Gallic acid(Seed), Gallic acid(Skin), Procyanidin B1-B4(-), Caffeic acid(-), Salicylic acid(-), Protocatechuic acid(-), Chlorogenic acid(-), Resveratrol(-), Ellagic acid(-) |
Polyphenol | Anthocyanins(Whole fruit) |
Tanin | Prodelphinidins(-) |
Traditional Practice | Diseases | Plant Part | Additional Knowledge |
Ayurveda | Fever and cough | Seed extract | Lower levels of neuropeptide Y, tumor necrosis factor alpha, and high sensitivity C-reactive protein[15] |
Ayurveda | Fever and cough | Seed extract | Reduces oxidative stress induced by On-pump Coronary Artery Bypass Surgery[16] |
4.1, 04.1.1, 04.1.1.1, 04.1.1.2, 04.1.2, 04.1.2.1, 04.1.2.11, 04.1.2.2, 04.1.2.4, 04.1.2.5, 04.1.2.7, 04.1.2.8, 04.1.2.9 |
Incompatible with Milk and Yogurt |
CSIR-North East Institute of Science and Technology, Jorhat-6, Assam, India
CSIR-Institute of Himalayan Bioresource Technology, Palampur-61,Himachal Pradesh, India |