Pyrus communis
Commonly known as Pear or Nashpati is grown in the sates of Punjab, Himachal pradesh, JK UT and Uttarakhand in large scale. It belongs to the family rosaceae and ot is generally harvested in the months of May and June. Pear peel contains a glycosylated hydroquinone known as Arutin which has been reported to have many biological property including antiproliferative activity and free radical scavenging activity.Arbutin can exert anticancer activity against rat C6 glioma cells by inducing apoptosis and inhibiting the inflammatory markers and P13/Akt/mTOR cascade and also can suppress osteosarcoma progression via miR-338-3p/MTHFD1L and inactivation of the AKT/mTOR pathway. |
Plant Details | Agro-climatic Zone | Vernacular Names | Pictures |
Scientific Name: Pyrus communis L. Family: Rosaceae L. Class: Magnoliopsida Order: Rosales Genus: Pyrus L. Fruiting Season: May – June and July – October Fruting Condition: Ripe |
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Himachal pradesh : naashapaatee, naashapaatee Karnataka : Marasebu Tamil Nadu : Pērikkāy, Pērikkāy |
Compound/Chemical | Immunomodulatory Activity | Pathway | Immunomodulatory Marker |
Arbutin | Antiproliferative activity | Arbutin can exert anticancer activity against rat C6 glioma cells by inducing apoptosis and inhibiting the inflammatory markers and P13/Akt/mTOR cascade | p13[3][4] |
Arbutin | Antiproliferative activity | Arbutin can suppress osteosarcoma progression via miR-338-3p/MTHFD1L and inactivation of the AKT/mTOR pathway | [3][4] |
Chlorogenic acid | Antioxidant activity | Free radical scavenging and protects against oxidative stress | [2][5][9] |
Syringic acid | Antiproliferative activity | Syringic acid acts as an anti-cancer agent by reducing cellular proliferation, inducing apoptosis, alteration of autophagy through modulating oxidative stress and key proteins involved in cellular proliferation | [1][8] |
Major Class | Metabolites |
Gycosylated hydroquinone | Arbutin(Peel), Arbutin(Peel) |
Phenolic acid | Chlorogenic acid(Pulp), Syringic acid(Pulp), Chlorogenic acid(Pulp), Syringic acid(Pulp) |
Traditional Practice | Diseases | Plant Part | Additional Knowledge |
Fruit | Reduced inflammatory factors and oxidative stress in patients with type 2 diabetes mellitus[10] |
04.1.1, 04.1.1 |
CSIR-North East Institute of Science and Technology, Jorhat-6, Assam, India
CSIR-Institute of Himalayan Bioresource Technology, Palampur-61,Himachal Pradesh, India |