Olea europaea
Olives have origin from the Mediterranean region, slow growing evergreen trees comprises of small silver-grey leaves and small creamy white flowers which later bears round green fruits that ripen to purple-black colour and has seeds in the centre of the fruit. It belongs to the Oleaceae family. It is a widely popular fruit since olive oil is generated from the seed of this fruit and is consumed throughout the globe. It is a very nutritious fruit comprising of various bioactive compounds such as Fatty acids (Myristic acid), Flavonoids (Luteolin, Quercetin, Chrysoeriol), Phenolic derivatives, Terpenes and so on. Oleuropein is a compound extracted from the fruit has been reported to exhibit antioxidant potential as it helps to inhibits the formation of intracellular ROS, and helps to elevate the expression of heme oxygenase-1 (HO-1) with activating the NF-E2 related factor 2. Again, Maslinic acid is another compound extracted has proven to exhibit inhibition of proliferation of against HT29 colon-cancer cells. Besides this, Ursolic acids, methyl Maslinate and Uvaol are other compounds found in the fruit which helps to boost the immune system. |
Plant Details | Agro-climatic Zone | Vernacular Names | Pictures |
Scientific Name: Olea europaea L. Family: Oleaceae Hoffmanns. & Link Class: Magnoliopsida Order: Lamiales Genus: Olea L. Fruiting Season: August-November Fruting Condition: Ripe |
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Matured fruit and plant. Plant bearing fruits. Whole plant. |
Compound/Chemical | Immunomodulatory Activity | Pathway | Immunomodulatory Marker |
Oleuropein | Anti-oxidant activity | The isolated compound oleuropein inhibits the formation of intracellular ROS, and increased the expression of heme oxygenase-1 (HO-1) via the activation of NF-E2-related factor 2 (Nrf2) transcription. | HO-1, NF-E2, Nrf2[7][8][10] |
Oleuropein | Anti-oxidant activity | In vivo, oleuropein was shown to increase the level and activities of enzymatic antioxidants such as superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRx), catalase (CAT) and enhance the level of non enzymatic antioxidants such as glutathione (GHS), α-tocopherol, β-carotene and ascorbic acid in alloxan-diabetic rabbits, rats fed a cholesterolrich diet and in acute arsenic exposed rats. | SOD, GPx, GRx, CAT, GHS[7][8][10] |
Maslinic acid | Anti-cancer activity | Maslinic acid, a triterpenoid reported from olive fruit, is an anti-tumor agent which showed potent anti-proliferative properties against the HT29 colon-cancer cells. | Inhibition of proliferation [1][12] |
Fruit extracts | Anti-inflamatory activity | Hexane extracts of O. europaea fruits showed the significant anti-inflamatory activity in swiss albino mice. It also exhibited antinociceptive activity against writhing-induced pain by acetic acid. In the xylene ear edema test, olive also showed significant anti-inflammatory activity in the mice. | [3] |
Major Class | Metabolites |
Fatty Acids derivatives | Myristic acid(Flesh) |
Flavone derivatives | Apigenin(Flesh) |
Flavonoid | Luteolin(Flesh), Quercetin-7-O-glucoside(Flesh), Quercetin(Flesh), Luteolin-7-O-rutinoside(Flesh), Apigenin-7-O-rutinoside(Flesh), Rutin(Flesh), Vicenin-2(Flesh), Chrysoeriol(Flesh), Chrysoeriol-7-Oglucoside(Flesh), Luteolin-7-O-glucoside(Flesh), Quercetin-3-rhamnoside(Flesh), Quercetin(Flesh) |
Glycosyl derivatives | 6-beta-glucopyranosyl oleoside(Flesh), 6-rhamnopyranosyl oleoside(Flesh) |
Hydroxytyrosol | Tyrosol(Flesh), Hydroxytyrosol(Flesh), Hydroxytyrosol rhamnoside(Flesh), Hydroxytyrosol glucoside(Flesh), Elenolic acid glucoside(Flesh) |
Iridoids | Ligstroside aglycone methyl acetal(Flesh) |
Pentacyclic triterpenoids | Erythrodiol(Flesh), Uvaol(Flesh), Ursolic acid(Flesh), Maslinic acid(Flesh) |
Phenolic derivatives | 3,4-dihydroxyphenylglycol(Flesh) |
Phenylpropanoids | Verbascoside(Flesh) |
Saccharolipids | Nuzhenide(Flesh), Nuzhenideoleoside(Flesh) |
Secoiridoids glycosides | Oleuropein(Flesh), Demethyloleuropein(Flesh) |
Sesquiterpenoids | Oleuroside(Flesh) |
Terpene alcohol | Delta-amyrin(Flesh), Taraxerol(Flesh), Cycloartenol(Flesh), 24-methylene cycloartenol(Flesh), 4-monomethylsterols,(Flesh), Obtusifoliol(Flesh), Cycloeucalenol(Flesh), Citrostadienol(Flesh) |
Terpene glycosides | Oleuropein(Flesh), Ligstroside(Flesh) |
Triacylglycerols, | Diacylglycerol(Flesh) |
Triterpenoids | Oleanolic acid(Flesh) |
Tyrosol derivatives | Tyrosol glucoside salidroside(Flesh), Methyl malate-𝛽-hydroxytyrosol ester(Flesh), 1-oleyltyrosol(Flesh), Cornoside(Flesh), 2(3,4-dihydroxyphenyl) ethanol(Flesh), Halleridone(Flesh), Hydroxytyrosol-elenolate(Flesh) |
Traditional Practice | Diseases | Plant Part | Additional Knowledge |
Unani | Anti-inflammatory | Plant isolate (oil) | olive oil polyphenols on antibodies against oxidized LDL.[15] |
Unani | Anti-inflammatory | Plant isolate (oil) | Antioxidant effect of virgin olive oil in patients with stable coronary heart disease[16] |
Unani | Anti-inflammatory | Plant isolate (oil) | Olive oils high in phenolic compounds modulate oxidative/antioxidative status[17] |
4.1, 04.1.1, 04.1.2.3, 04.1.2.10, 04.1.2.6, 04.1.1 |
Incompatible with dairy products and other acidic fruits such as Grapes, Amla and Papaya etc. |
CSIR-North East Institute of Science and Technology, Jorhat-6, Assam, India
CSIR-Institute of Himalayan Bioresource Technology, Palampur-61,Himachal Pradesh, India |