Morinda citrifolia
Noni is a well-known Indian origin fruit belonging to the Rubiaceae family. The fruit is ovoid shaped covered by polygonal-shaped sections or divisions. It reaches to a length of upto 12cm. the fruit is hard and bright green in colour initially and later during ripening stage it turns soft and changes its colour to yellow or off-white. In phytochemical investigations, it has been observed that the fruit contains anthraquinones (rubiatin, damnacanthal, alizarin-1-methyl ether and sterols); fatty acids, glycosides, alcohols, iridoids (asperuloside, asperulocide acid and deacetylaperulosidic acid). Fatty acids and iridoids were reported to inhibit ester- and EGF-induced AP-1 (transcription activator protein-1) transactivation and cell transformation in JB6 cells. Along with this the fruit also helps to release the cytokines such s TNF-alpha, IL-1beta, IL-10 and IF-gamma but not IL-2. |
Plant Details | Agro-climatic Zone | Vernacular Names | Pictures |
Scientific Name: Morinda citrifolia L. Family: Rubiaceae Juss. Class: Magnoliopsida Order: Gentianales Genus: Morinda L. Fruiting Season: June-September; October-December Fruting Condition: Ripe |
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Andhra Pradesh : Mogali Goa : Bartondi Gujarat : Surangi Karnataka : Tagase Maddi Kerala : Cherumanjanathi, Kattapitalavam, Manjanathi, Manjanathi, Mannapavatta Maharashtra : Nagakunda Odisha : Pindre Tamil Nadu : Noni, Nuna West Bengal : Hurdi |
Immature fruits. Raw fruit sliced. Fruit and plant. |
Compound/Chemical | Immunomodulatory Activity | Pathway | Immunomodulatory Marker |
Fruit extract | Anti-inflammatory activity | The alcohol extract of Noni fruit at various concentrations inhibits the production of tumour necrosis factor-alpha (TNF-alpha). | TNF-alpha[1][2] |
Fruit extract | Anti-inflammatory activity | Noni precipetate is also capable of stimulating the release of many mediators from murine effector cells including TNF-alpha, IL-1beta, IL-10, IL-12 and IFN-gamma and NO. | TNF-alpha, IL-beta, IL-10, IL-12, IFN-gamma and NO inhibition.[1][2] |
Fermented fruit | Anti-inflammatory activity | Fermented Morinda citrifolia(FNONI) reduces levels of histamine, IgE and IgG1/IgG2a ratio, thymus and activation regulated chemokine (TARC), and thymis stromal lymphoprotein (TSLP) in serum and modulates the expression of Th1, Th2, Th7 and Th-22 mediated cytokines. | [1] |
Seed extract of the fruit | Anti-inflammatory activity | The seed extract of M.citrifolia helps to reduce the production of nitric oxide (NO) and TNF-alpha. | NO inhibition and TNF-alpha[1][2][3] |
Fruit extract | Antioxidant activity | The fruit extract of Noni shows excellent Antioxidant activity by free radical scavenging and which also dependent on doses but is higher than that of ascorbic acid. | [4] |
Major Class | Metabolites |
Scopoletin(Fruit), Caproic acid(Fruit), Octoanoic acid(Fruit), b-sitosterol(Fruit), Carotene(Fruit), Linoleic acid(Fruit), Alizarin(Fruit), Acubin(Fruit), L-asperuloside(Fruit), Caprylic acid(Fruit), Ursolic acid(Fruit), Rutin(Fruit), Putative proxeronine(Fruit), Nonioside A(Fruit), Tricetin(Fruit), (2E,4E,7Z)-deca-2,4,7-trienoate-2-O-β-d-glucopyranosyl-β-d-glucopyranoside(Fruit) | |
Anthraquinones | Nordamnacanthal(Fruit), Morindone(Fruit), Rubiadin(Fruit), Rubiadin1-methyl ether(Fruit), Anthraquinone glycoside(Fruit) |
Coumarin | Scopoletin(Fruit) |
Flavonoid | Anthocyanin (cyanidin-3-O-rutinoside)(Fruit), Catechin(Fruit), Epicatechin(Fruit), Kaempferol(Fruit), Rutin(Fruit), Quercetin(Fruit) |
Iridoids | Asperulosidic acid(Fruit) |
Lignan | Americanin A(Fruit), Americanol A(Fruit), Isoprincepin(Fruit), Lirioresinol B(Fruit), Lirioresinol B dimethyl ether(Fruit), Morindolin(Fruit), 3,3’-Bisdemethypinoresinol(Fruit) |
Phenolic Acid | Chlorogenic acid(Fruit), Gentisic acid(Fruit), P-hydroxybenzoic acid(Fruit) |
Terpenoid | Ursolic acid(Fruit), Saponin(Fruit) |
Traditional Practice | Diseases | Plant Part | Additional Knowledge |
Fruit | Antibacterial efficacy and effect of Morinda citrifolia L. mixed with irreversible hydrocolloid for dental impressions[5] |
04.1.1, 04.1.1.1, 04.1.2.10, 04.1.2.2 |
Not incompatible with anything. |
CSIR-North East Institute of Science and Technology, Jorhat-6, Assam, India
CSIR-Institute of Himalayan Bioresource Technology, Palampur-61,Himachal Pradesh, India |