Litchi chinensis
Lychee is a tropical fruit of the Sapindaceae family. It is small, round with red scaly skin, sweet juicy pulp with one large seed. It is also known as Litchi and is very popular in all the states of the country. The fruit contains a good amount of many bioactive compounds such as Phenolic acids, flavonoids, Terpenoids, Anthocyanidins and so on. Epicatechin, Proanthocyanidin B2 and Proanthocyanidin B4 are Anthocyanidins present in the fruit which are known to stimulate the secretion of Thn1 cytokine IFN-gamma and inhibits the secretion of Th2 cytokine IL-4, hence helping to boost the immunity. It has antioxidant activities like, Upregulating the endogenous antioxidant enzyme activities, inhibiting the generation of ROS. Similarly, it has other immune-boosting activities like, anti-inflammatory activity, anticancer activity and so on. |
Plant Details | Agro-climatic Zone | Vernacular Names | Pictures |
Scientific Name: Litchi chinensis Sonn. Family: Sapindaceae Juss. Class: Magnoliopsida Order: Sapindales Genus: Litchi Sonn. Fruiting Season: April-June Fruting Condition: Ripe |
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Whole plant. Ripe litchies with plant. Whole fruit. Ripe fruits |
Compound/Chemical | Immunomodulatory Activity | Pathway | Immunomodulatory Marker |
Epicatechin, proanthocyanidin B2, and proanthocyanidin B4 | Immunomodulatory activity | Stimulates the secretion of Th1 cytokine IFN-γ. Inhibits the secretion of Th2 cytokine IL-4. | Th-1, Th-2, IFN-gamma, IL-4[1][2][3] |
Epicatechin, proanthocyanidin B2, and proanthocyanidin B5 | Immunomodulatory activity | Enhances the expression of T-bet. | T-bet[1][2][3] |
Epicatechin, proanthocyanidin B2, and proanthocyanidin B6 | Immunomodulatory activity | Inhibits the expression of GATA-3. | GATA-3[1][2][3] |
Epicatechin, proanthocyanidin B2, and proanthocyanidin B7 | Immunomodulatory activity | Promotes the development of cell cycle toward the S phase. | [1][2][3] |
Cinnamtannin B2 | Anti-oxidant activity | Inhibition of ROS generation | ROS[6] |
Fruit extract | Anti-inflamatory activity | Enhances basal PGE2 production. | PGE2[5] |
Fruit extract | Anti-inflamatory activity | Suppress the expression of inflammatory genes | MAPK signalling[5] |
Fruit extract | Anti-inflamatory activity | Inhibition of NF-kB activation and mRNA-asRNA interactions | NF-kB[5] |
Major Class | Metabolites |
Anthocyaninss | Cyanidin-3-glucoside (Flesh), Cyanidin-3-rutinoside (Flesh), Malvidin-3-glucoside (Flesh) |
Coumarins derivatives | Scopoletin (Flesh) |
Dihydrochalcones | Dihydrocharcone-4′-O-β-D-glucopyranoside (Flesh) |
Fatty Acids derivatives | Methyl dihydrosterculate (Flesh), 2,5-Dihydroxy-hexanoic acid (Flesh), Litchioside C (Flesh) |
Flavonoid | Epicatechin(Flesh), Catechin(Flesh), Gallocatechin(Flesh), Epicatechin-3-gallate(Flesh), Epicatechin-(7,8-bc)-4β-(4-hydroxyphenyl)-dihydro-2(3H)-pyranone(Flesh) |
Flavonols | Kaempferol (Flesh), Quercetin (Flesh), Kaempferol-7-O-β-D-glucopyranoside (Flesh), Kaempferol-7-O-neohesperidoside (Flesh), Quercetin-3-O-rutinoside (Flesh), Quercetin-3-O-rutinoside-7-O-α-L-rhamnoside(Flesh), Tamarixetin 3-O-rutinoside (Flesh), Narcissin (Flesh) |
Flavonones | Narirutin (Flesh), Naringin (Flesh), (2R)-Pinocembrin-7-neohesperidoside (Flesh), Litchioside D (Flesh), (–)-Pinocembrin-7-O-neohesperidoside (Onychin) (Flesh), Pinocembrin-7-O-glucoside (Flesh), (2S)-Pinocembrin-7-O-(6′′-O-α-L-arabinosyl-β-D-glucopyranoside) (Flesh), Pinocembrin-7-O-[(6′′-O-β-D-glucopyranoside)-β-D-glucopyranoside](Flesh) |
Glycerophosphates | Phosphatidylglycerol(Flesh) |
Lignanes | Isolariciresinol(Flesh) |
Phenolic acid | Protocatechuic acid (Flesh), Coumaric acid (Flesh), Caffeic acid (Flesh), Methyl -3,4-dihydroxybenzoate (Flesh), Gallic acid (Flesh), 2-(2-Hydroxy-5-(methoxycarbonyl) phenoxy)benzoic acid (Flesh), Butylated hydroxytoluene (Flesh), Gentisic acid (Pulp), Sinapic acid(Pulp), Epicatechin(Pulp) |
Phenylalanine | Chlorogenic acid (Flesh) |
Proanthocyanidins | Proanthocyanidin A1(Flesh), Procyanidin A2(Flesh), Proanthocyanidin A6(Flesh), Litchitannin A1 (Flesh), Litchitannin A2(Flesh), Aesculitannin A (Flesh), Propelargonidin (Flesh), Procyanidin (Flesh), Prodelphinidin (Flesh), Proanthocyanidin B4 (Flesh), Cinnamtannin B1 (Flesh), 2α,3α-epoxy-5,7,3`,4`-tetrahydroxyflavan-(4β-8-catechin) (Flesh), 2α,3α-epoxy-5,7,3`,4`-tetrahydroxyflavan-(4β-8-epicatechin) (Flesh), 2β,3β-epoxy-5,7,3`,4`-tetrahydroxyflavan-(4α-8-epicatechin) (Flesh) |
Sesquiterpenes | Litchioside A (Flesh), Litchioside B (Flesh), Pumilaside A (Flesh), Funingensin A (Flesh), Pterodontriol-D-6-O-β-D-glucopyranoside (Flesh) |
Triterpenoids | Stigmasterol (Flesh) |
Traditional Practice | Diseases | Plant Part | Additional Knowledge |
Fruit | Alleviates Liver Steatosis and Gut Dysbiosis in Patients with Non-Alcoholic Fatty Liver Disease[11] |
04.1.1, 04.1.1.1, 04.1.2.9 |
Incompatible with milk and other dairy products. |
CSIR-North East Institute of Science and Technology, Jorhat-6, Assam, India
CSIR-Institute of Himalayan Bioresource Technology, Palampur-61,Himachal Pradesh, India |