Hippophae rhamnoides
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Sea buckthorns belongs to the family Elaeagnaceae. The fruits are in the form of yellow-orange berries and these berries have been used food, traditonal medicine and skin tratment in Mangolia ,Russia and Ladakh region in India.The plant can subzero temperatures. The fruits of Sea bukthorn are rich in carotenoids and other secondary metabolites which are shown to have immunomodulatory activity. Quercetin one of the major compound in Sea buckthorn was reported to have antiproliferative activity by increasing cell apoptosis and inhibits cell cycle progression Increases FasL mRNA expression and p51, p21, and GADD45 signaling activities. Induces protein level, transcriptional activity, and nuclear translocation of Foxo3a in breast cancer cells. |
| Plant Details | Agro-climatic Zone | Vernacular Names | Pictures |
| Scientific Name: Hippophae rhamnoides L. Family: Elaeagnaceae L. Class: Magnoliopsida Order: Rosales Genus: Hippophae L. Fruiting Season: August - September Fruting Condition: Ripe |
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Himachal pradesh : chharma, chharma Ladakh : chharma, chharma |
| Compound/Chemical | Immunomodulatory Activity | Pathway | Immunomodulatory Marker |
| Gallic acid | Antiproliferative activity | Gallic acid induces apoptosis in A549 lung cancer carcinoma cells by elevation of ROS, disrupting MMP and activating caspase 3 | Caspase 3[1][2] |
| Gallic acid | Antioxidant activity | Free radical scavenging | NA[1][2] |
| Quercetin | Antiproliferative activity | Quercetin increases cell apoptosis and inhibits cell cycle progression Increases FasL mRNA expression and p51, p21, and GADD45 signaling activities. Induces protein level, transcriptional activity, and nuclear translocation of Foxo3a in breast cancer cells | p51, p21 |
| β-Carotene | Antioxidant activity | Free radical scavenging | NA[3][4] |
| Major Class | Metabolites |
| Carotenoids | β-Carotene(Pulp), β-Carotene(Pulp) |
| Flavonoid | Quercetin(Pulp), Quercetin(Pulp) |
| Phenolic acid | Gallic acid(Pulp), Gallic acid(Pulp) |
| Traditional Practice | Diseases | Plant Part | Additional Knowledge |
| Plant isolate (oil) | Oral sea buckthorn oil attenuates tear film osmolarity and symptoms in individuals with dry eye[6] | ||
| Plant isolate (oil) | Sea buckthorn berry oil inhibits platelet aggregation[7] | ||
| Fruit | Postprandial hyperglycemia and insulin response are affected by sea buckthorn berry and its ethanol-soluble metabolites[8] |
| 04.1.1, 04.1.1 |
| CSIR-North East Institute of Science and Technology, Jorhat-6, Assam, India
CSIR-Institute of Himalayan Bioresource Technology, Palampur-61,Himachal Pradesh, India |