Citrus maxima
Pomelo is one of the largest fruits among all citrus fruits of the Rutaceae family and it is also very popularly known as the ancestor of grapefruit. This fruit has a red coloured, sweet and juicy pulp and the rind turns from green to yellow while turning ripe. The fruit possesses high nutritional and medicinal values due to the presence of abundant bioactive compounds comprising of antioxidant and anti-inflammatory activities. Coumarin present in the fruit exhibits anti-inflammatory activity by inhibiting IL-1beta, PGE2 and TNF-alpha in LPS stimulated RAW 264.7 cells without any toxicity. In ripe conditions, the bioactive compounds, limonene, terpinene, pinene and citral contents are reported to be found in higher concentrations than the others. |
Plant Details | Agro-climatic Zone | Vernacular Names | Pictures |
Scientific Name: Citrus maxima (Burm.) Merr. Family: Rutaceae Juss. Class: Magnoliopsida Order: Sapindales Genus: Citrus L. Fruiting Season: July-September Fruting Condition: Ripe |
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Andhra Pradesh : Pamparapanasa Assam : Chakotara, Robab Tenga Goa : Toranda Gujarat : Papanas Karnataka : Cakota hannu Kerala : Kampilinaranna Maharashtra : Bampara, Cakotra, Papannasa Manipur : Nobab Mizoram : Kamalo, Sertawk Nagaland : Huolo, Pfulo Odisha : Batapi Tamil Nadu : Metukku, Pampalimacu, Pommacu West Bengal : Batabi Lebu, Cholanga, Jambura Lebu |
Ripe Pomelo. Unripe fruit. |
Compound/Chemical | Immunomodulatory Activity | Pathway | Immunomodulatory Marker |
Methanolic acetate extract, Coumarin fraction | Anti-inflammatory activity | Coumarins of he fruit in in vitro analysis exhibited their action by inhibiting IL-1beta, PGE2 and TNF-alpha in LPS stimulated RAW264.7 cells without any toxicity at 5ug/ml concentration. | IL-1beta, PGE2, TNF-alpha[1] |
Flavonoid | Antioxidant activity | The falvonoids specially works ase a scavenger of free radicals and exhibits all other types of immune responses or activities. | [1] |
Fruit juice | Antihyperlipidemic activity | The fruit juice of Citrus maxima is administered to decrease serum cholesterol and triglyceride levels and HDL (High Density Lipoprotein)-cholesterol in STZ-induced diabetic rats. | HDL-cholesterol[1] |
Fruit juice | Antihyperlipidemic activity | The juice also increases plasma HDL levels and decreases the level of LDL (Low Density Lipoprotein) cholesterol. | HDL and LDL cholesterol[1] |
Polysaccharide | Anti-inflammatory activity | The Polysaccharides of the fruit inhibits the activity of various inflammatory mediators such as IFN-alpha, IL-2 and IL-4. | IFN-alpha, L-2, IL-4[1] |
Major Class | Metabolites |
Lutein(), Zeaxanthin(), Lycopene(), Aurapte(Peel), Auraptene(Peel), 5-Geranyloxy-7-methoxy-coumarin(Peel), Roseoside(Peel), Bergamottin(Peel), Limolin(Seed), Nomilin (Seed) | |
Carotenoid | α-carotene(Fruit), β-carotene(Fruit), β-cryptoxanthin() |
Flavonoid | Hesperetin(Fruit), Naringenin(Fruit), Eriodictyol(Fruit), Nobiletin(Fruit), Tangeretin(Fruit), Sinensetin(Fruit), Diosmetin(Fruit), Luteolin(Fruit), Apigenin(Fruit), Neohesperidin(Fruit), Naringin(Fruit), Rutin(Fruit) |
Traditional Practice | Diseases | Plant Part | Additional Knowledge |
04.1.1, 04.1.1.1 |
Incompatible with dairy products and other acidic fruits such as Grapes, Amla and Papaya etc. |
1 . DOI: 10.1177/2515690X211043741 |
CSIR-North East Institute of Science and Technology, Jorhat-6, Assam, India
CSIR-Institute of Himalayan Bioresource Technology, Palampur-61,Himachal Pradesh, India |